Chalk Mixture Research 1p3729

CHALK MIXTURE Antacid USES: Antacid Gastrointestinal Agent INDICATIONS: Indigestion and Dyspepsia. CONTRAINDICATIONS: Adverse reaction to antacids and antigastric secretion drugs. SIDE EFFECTS: Constipation. PRECAUTIONS: Before you use this medicine, Do not use the medicine if:     Liver Disease Avoid chalk in water retention in liver disease.     Renal Failure Consider dose reduction in renal failure to avoid possibility of toxicity, increased sensitivity and side effects.     Pregnancy Drugs can have harmful effects on the fetus at any stage of pregnancy. Experience with many drugs is limited. CHALK should only be used if expected benefit outweighs possible risk. PHARMACOLOGIC ACTIONS: Antacid Effect. FORMULATION NOTES: Chalk is practically insoluble in water and is an undiffusable solid which requires a suspending agent. Tragacanth powder is used in this formulation. The concentrated cinnamon water is a flavoring agent and the syrup increase the viscosity as well as acting as a sweetener. Chloroform water is the preservative. METHOD OF PREPARATION: The chalk and tracaganth should be weighed and lightly mixed in a mortar and pestle. Add the syrup and mix to make a paste. The double strength chloroform water should be gradually added, with mixing, followed by the concentrated cinnamon water. The mixture should be rinsed into a previously tared 100ml amber medicine bottle and made up to the volume with water. Shake the suspension well and seal with a child resistant closure. Polish and label the bottle and give a 5ml medicine spoon with the medicine

SHELF LIFE AND STORAGE: Store in a cool, dry place. It is freshly prepared, therefore a shelf life of 1 week is applicable. ADVICE AND LABELLING: ‘Shake well before use’. Advice on the importance of fluid replacement using oral rehydration sachets should be given if necessary. REFERENCE: http://216.122.144.54/cgi-bin/drugcgic/INGR?136876289+0#CONTRAIND GROUP 5 PH3Y2-2

PHM 325 MS. ORTEGA