Th Silfradent April 2016 2l67
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MEDIFUGE
NEW SCIENCE NEW SOLUTIONS NEW APPLICATIONS
CONTENT 1. Introduction to Silfradent Company and development of Medifuge 2. Medifuge and CGF. 3. How to use Medifuge? 4. Main CGF Medical Application 4.1 Dental Clinic Application 4.2 Other major Medical applications 5. Advantages and Disadvantage 6. Related product (Round Up, & APAG) and accessories 7.Study and clinical paper 8.Technical specification for Round up
1. Introduction of Sifradent Company
Silfradent is located in Santa Sofia, in the heart of a charming National Park, at the borders between Romagna and Tuscany provinces, in Italy. Since 1975 the Silfradent Company specializes in the production of instruments for dental laboratories, but since 2003 Silfradent also produces medical equipments. The constant of engineers, professors and doctors with its motivated staff and its organized distribution network of importers have helped Silfradent become the leading company in world in all of European Community, North Africa, Arabic countries, China, South Korea, South East Asia, Australia and the countries of South America and USA.
1. Introduction of Silfradent Company and development of Medifuge Today is the world leader in the most advance techniques of Growth Factors. Our scientific research and clinical outcomes demonstrate uniqueness and effectiveness of our new CGF system using Concentrated Growth Factors & Stem Cells. Silfradent offers a unique, incomparable, easy to handle and scientifically tested system. Reduce the pain and the intra & post-operative complication.
The MEDIFUGE CGF is designed to process blood to obtain CGF in a sterile environment so as not to contaminate the material to be implanted.
2. Introduction of Medifuge and CGF CGF - A dream of every doctor: A “fabulous” material that could cure all wounds quickly and avoid the secondary complications of surgical and medical procedures.
“Direct "effect of the growth factors Cytokines and CD 34 + cells Repair, regeneration, pain relief, Inflammation, minimizes swelling "Indirect" effect of growth factors, Cytokines and CD 34+ cells Signal transmission and thus more production growth factors and cytokines, as well as immigration into the tissue of other stem cells
2. Introduction of Medifuge and CGF
ROTOR PHASE SEPARATOR: SIFRADENT’S ADVANCE
•
Controlled acceleration
•
Cycle Bleaching sterilizing= decontamination
•
Antistatic, anti-magnetic rotor
•
Self-ventilation to control temperature
•
Deceleration control
•
Cooling
•
Temperature control
•
Self-decontamination
•
Rotor with alternate and controlled speed with an acceleration always under RCF300
2. Introduction of Medifuge and CGF
ROTOR SEPARATOR: SIFRADENT’S ADVANCE
PHASE
Rotor antistatic antimagnetic material (No influence on Fe in the red blood cells, minerals, heavy metals, decresaes cancer promoting substances as Aflatoxins, Cerium,Pollonium, eliminates Clostridium) Differentiated acceleration Speed and fractional – alternating RCF (does not allow the platelet degranulation) Constant temperature maintained by self ventilation
2. Introduction of Medifuge and CGF
ACCESSORIES’ MEDIFUGE
2. Introduction of Medifuge and CGF WHAT’S THE CGF? CGF – There is no blood manipulation CGF – It is a protein CGF – Stimulates – Accelerates natural biological events CGF – Block of fibrin and other blood-phases, a slow and continuous polymerization CGF – It transforms – It is an autologous material which don’t needs reabsorption CGF – Block fibrin flexible tri-molecular network – plasma cytokines stop in places/parking. CGF – Made with tissue fibroblasts are created – Made with bone osteoblasts are created. It doesn’t cause but accelerates the healing. CGF – Immunizing Anti edemigeno “swelling” Healing It acts in an intrinsic and extrinsic way CGF – Neo angiogenesis It rebuilds the blood vessels after 24 hours in the concave cavities where is necessary to accelerate the vascularization. Angio-vessel / Genesis-birth CGF – Immunogenic. It prevents the attack by bacteria and their fertility.
2. Introduction of Medifuge and CGF
WHAT’S THE CGF?
PDGF: Platelet Derived Growth Factor Promote the growth of blood vessels, cell replication, skin repair VEGF*: Vascular Endothelial Growth Factor Promote the formation of blood vessels EGF: Epidermal Growth Factor Promote cell growth and cell differentiation TGF-b*: Trasforming Growth Factor b Promote the growth of the extracellular matrix, the bone metabolism FGF-2*: Fibroblast Growth Factor-2 Promote cell growth and the formation of vessels IGF: Insulin-like Growth Factor Regulator of normal physiological processes of almost all types of body cells
2. Introduction of Medifuge and CGF
PROCESSES PROMOTED BY CGF AND ITS MAIN CHARACTERISTICS •
It is a preparation of autologous.
•
Immunologically neutral.
•
Non-toxic.
•
Stimulating repair processes and growth tissue.
•
Stimulating cell proliferation.
•
Stimulating angiogenesis and revascularization.
•
Stimulating the proliferation of mesenchymal cells.
•
Stimulating the production of fibroblasts.
•
Accelerating wound healing.
•
Bio - Stimulating collagen production.
•
The thin, soft, elastic and permeable mesh allows to be colonized by repair cells, red and white blood cells, platelets
3. How to use Medifuge? Collect the blood of the patient from 2 to 8 Vacuettes ® (tube) 18 cc (2 tubes) to 72 cc (=ml ) of blood red, white or green cap Put immediately in the Medifuge
3. How to use Medifuge? Safe & proper technique for routine blood draw
3. How to use Medifuge? Safe & proper technique for routine blood draw Steps • Apply the tourniquet • Palpate the antecubital fossa and locate the median cubital vein • Cleanse the skin around the site in a fluid • circular motion from the center to the periphery. • Position the needle bevel side up and linen with the vein in an ankle of maximum 30° • Draw blood • Instruct the client to open his hand and remove the tourniquet • Apply pressure in the puncture site immediately after and safe it with an adhesive bandage
3. How to use Medifuge? In each label there is the expiry date and the level of the quantity of blood need to collect =9 cc=9 ml
3. How to use Medifuge?
VACUTAINER® TUBES
Three types of Vacutainer and Applications of each separated part.
"Z serum clot activator" with Red cap internal coating by using silicon crystals in a coagulum the separation / centrifugation is done at room temperature
"Z No Additives" with White Cap no additional exogenous or coating here gelled a coagulum after separation / centrifugation after approximately 20 min at room temperature
"Sodium heparin" with Green Cap: Sodium heparin tube-fed to prevent the coagulation remain liquid at 20oC for 8 hours and at 4oC for 40 h. liquid
3. How to use Medifuge?
MEDIFUGE MF 200
Immediately after blood drawing (2 min.), set the vacutainers® opposite to each other in the Medifuge. Color-different cap tubes can be put together. Warning: Never put uneven tubes!
The load in a centrifuge must be carefully balanced. Use a combination of samples and balance tubes which all have the same weight or use various balancing patterns without balance tubes. Difference in mass of the tubes can result in a large force imbalance when the rotor is at high speed. This force imbalance strains the spindle and may result in damage to the centrifuge or personal injury.
3. How to use Medifuge? With the evolution of the CGF system , with Medifuge we obtain the 4 separated layers
4. Main CGF Medical Application Implantology, Oral Surgery, Peri-implantitis & Osteonecrosis Treatment, Bone Regeneration GBR, Tissue Regeneration GTR, Socket Preservation, Sinus Floor Elevation, IPG DET, Bone Grafting, Aesthetic of Peri-oral area, Biological Guided Periodontitis, ...... Trigeminus neuralgia TMJ regenerative therapy Facial Aesthetics, Autologous Messtherapy, Scars, Wrinkles, Skin regeneration & Hair aesthetics Biological Orthopaedic treatments for: bone, cartilage, sclerotic or inflamated tendons and muscles
4.1 Dental Application RED CAP TUBE : CGF – SOLID PHASE BLOOD COLLECTION AND VACUUM SEPARATION RED CAP TUBE
C.G.F.
CONCENTRATED
GROWTH FACTORS – SOLID PHASE •
Red
cap
tube
–
with
phases
separator
Medifuge, you
obtain a
fibrine clot platelet gel •
For
the
preparation
autologous
of
suturable
membrane, particulate to mix
with
autologous,
heterologous or synthetic bone.
4.1 Dental Clinic Application
3.1. RED CAP TUBE : CGF – SOLID PHASE LAYERS OF THE CGF SYSTEM RED CAP - WITH SILIZIUM COATING
4.1 Dental Clinic Application • In sinus lift procedures, CGF accelerates the healing and reduces the healing time with stable bone gain. • Ridge augmentation can be achieved with the use of CGF. • Socket preservation to maintain the alveolar bone height. • Intrabony defects or osseous defects have shown bone fill. • Optimal treatment for peri-implantitis. • Filling of cystic cavity. • Treatment of furcation defect. • Jaw reconstruction surgeries. • In the treatment of combined periodontic endodontic lesion. • Soft tissue procedures like gingival grafts, subepithelial grafts, and so forth, because of the property of GGF of accelerating soft tissue healing • Temporo Mandibular TMJ Articular Regeneration
4.1 Dental Clinic Application
MEMBRANES FOR GRAFTS COVERING
4.1 Dental Clinic Application
MEMBRANES FOR GRAFTS COVERING
4.1 Dental Clinic Application
MEMBRANES FOR GRAFTS COVERING
4.1 Dental Clinic Application
MEMBRANES FOR GRAFTS COVERING
4.1 Dental Clinic Application
MEMBRANE THAT POSSESSES ELASTICITY AND FLEXIBILITY
Image Dr. Ezio Gheno
4.1 Dental Clinic Application
4.1 Dental Clinic Application PERI-IMPLANTITIS & OSTEONECROSIS TREATMENT
4.1 Dental Clinic Application
CGF-CD34+Matrix & Peri-implantitis
Biological Guided Peri-iplantitis Treatment www.dentistedu.com
Bone reconstruction in 45 days
4.1 Dental Clinic Application
CGF-CD34+Matrix & Peri-implantitis Biological Guided Peri-implantitis Treatment
www.dentistedu.com
4.1 Dental Clinic Application
CGF-CD34+Matrix & Peri-implantitis Biological Guided Peri-iplantitis Treatment
Pre-op
3 months Post-op
3 years Post-op
“DentistEdu” special protocol for Peri-implantitis & Osteonecrosis Dentist Education Institute, Athens - Greece www.dentistedu.com
4.1 Dental Clinic Application
IPG DENTISTEDU DENTISTEDU TECHNIQUE TECHNIQUE IPG
I.P.GEORGAKOPOULOS ET ET ALL, ALL, JOURNAL JOURNAL OF OF IMPLANT IMPLANT AND AND ADVANCED ADVANCED CLINICAL CLINICAL I.P.GEORGAKOPOULOS DENTISTRY, VOLUME VOLUME 6, 6, NO NO 1, 1, 20-01-2014 20-01-2014 DENTISTRY,
Direct placement of seven implants in the posterior areas of the maxilla of a 49 year old female patient utilizing the flapless technique. The implants were introduced into both the sinus cavities with intentional perforation of the sinus membrane. CGF-CD34+ Matrix, Democritus' allograft & Combioss alloplastic bone materials were used in this case, following a certain protocol Dentist Education Institute, Athens - Greece
www.dentistedu.com
4.1 Dental Clinic Application
IPG DentistEdu Technique Results: 8 months Post-op
New bone formation around the implants I. P. Georgakopoulos et all, JIACD 2014
Almost 10 mm of new bone formation over the sinus floor
Conclusions: IPG-DentistEdu Technique promising results demonstrate that it can be considered as a reliable alternative to the SFE procedure.
4.1 Dental Clinic Application
IN THE SINUS LIFT PROCEDURE CGF ACCELERATES THE HEALING AND REDUCE THE HEALING TIME
After careful elevation of the sinus membrane, 4 pieces of fibrin-rich block were inserted into the new compartment between the elevated membrane and the sinus floor. Two tapered design implants were placed simultaneously after a 1-step down osteotomy. The
4.1 Dental Clinic Application
The piezoelectric saw, connected to piezoelectric device (Surgybone, Silfradent srl), was used to create the replaceable lateral window of maxillary sinus in all cases.
Cone-beam computed tomogram showing 1 to 2mm bone height at the right maxillary second (left) and first molar (right), respectively (from patient number 50).
4.1 Dental Clinic Application
The bony window was repositioned with stability to seal the window. f, Cone-beam computed tomographic scans revealed new bone consolidation along the implant body at the right maxillary second (left) and the first molar (right), respectively, after 18 weeks healing. Implants were uncovered at this stage.
Cone-beam computed tomogram showing 1 to 2mm bone height at the right maxillary second (left) and first molar (right), respectively (from patient number 50).
4.1 Dental Clinic Application
Radiogram after 5 months loading. Note the newly formed bone in the sinus.
4.1 Dental Clinic Application
IMPLANTOLOGY FASTER HEALING REDUCING COMPLICATIONS
4.1 Dental Clinic Application
BONE RING
4.1 Dental Clinic Application
BONE RING
4.1 Dental Clinic Application
BONE RING You mix the bone ring after drilling the implant site in the round up (6 sec.) and then fix the the bone ring with the implant.
BONE REGENERATION IN THE MAXILLARY SINUS USING AN AUTOLOGOUS FIBRIN-RICH BLOCK WITH CONCENTRATED GROWTH FACTORS ALONE Dong-Seok Sohn, DDS, PhD, Jeung-Uk Heo, DDS, PhD, Dong-Ho Kwak, DDS, PhD, Dong-Eung Kim, DDS, PhD, Ji-Min Kim, DDS, Jee-Won Moon, DDS, Ju-Hyoung Lee, DDS, and In-Sook Park, DDS, PhD
A fibrin-rich block with concentrated growth factors. The second and third layers were utilized for sinus augmentation.
4.2 Other major Medical Applications WHITE CAP TUBE : CGF – LIQUID PHASE (LPCGF) BLOOD COLLECTION AND VACUUM SEPARATION WHITE CAP TUBE
C.G.F.
CONCENTRATED
GROWTH FACTORS – LIQUID PHASE (LPCGF) •
White
cap
tube:
phases
with
separator
Medifuge, you obtain a liquid phase for infiltration treatments
to
be
used
within 20/30 minutes from the separation. •
After
this
separated naturally jells.
time
the
material
4.2 Other major Medical Applications
LAYERS OF THE CGF SYSTEM - WHITE CAP – WITHOUT COATING OR ADDITIONAL SUBSTANCES
4.2 Other major Medical Applications
AESTHETIC AND COSMETIC APPLICATION • Full face rejuvenation • Cell regeneration • Facial volumization • Acne scars • Facial aesthetic lipostructure • Elimination of spots tissue • Wrinkled neck and décolleté • Fine lines and wrinkles • Textural improvement • Dull dry skin • Backs of hands
• Areas with androgenetic alopecia or alopecia aerated
4.2 Other major Medical Applications
LOSS HAIR: AREAS WITH ANDROGENETIC ALOPECIA OR ALOPECIA AREATED
4.2 Other major Medical Applications
LPCGF ON LEFT EYE. BEFORE & 6 WEEKS AFTER PROCEDURE
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
TYPICAL SKIN DAMAGE DUE TO EXTENSIVE SUN– EXPOSURE AND NICOTINE ABUSE
SKIN REPAIR AFTER 6 WEEKS WITH LPCGF
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
STROKE WIDTH REDUCTION AND PIGMENTATION IMPROVEMENT AFTER CGF – LPGF PROCEDURES
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
IMPROVEMENT OF LAX SKIN
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
HAND REJUVENATION
Aesthetic treatment of Dr. Paola Pederzol
4.2 Other major Medical Applications
STRIAE AFTER 2 MONTHS
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
OILY SKIN, BIG PORES, BEFORE & AFTER LPCGF
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
AGED SKIN WITH WRINKLES AND PIGMENTATION PROBLEMS 3 MONTHS AFTER LPCGF
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications 4 SESSIONS OF MICRONEEDLING
4.2 Other major Medical Applications BURN SCARS 1 TREATMENT WITH CGF –
4.2 Other major Medical Applications
3 MONTHS POST-OP
4.2 Other major Medical Applications
BURN SCARS ON FOREARM
Improvement after 1 treatment, 3 month post-op. CGF – best choice for burn scars!
4.2 Other major Medical Applications
FACIAL BURN SCARS
3 months post-op
4.2 Other major Medical Applications
ONE TREATMENT 7 MONTHS POSTOP
4.2 Other major Medical Applications
Only in needled areas erythema improves significantly
4.2 Other major Medical Applications
Only in needled areas erythema improves significantly This might be a hint that erythema of “lasered” skin can be reduced by micro needling
4.2 Other major Medical Applications
In the left photo erythema is observed along the keloid scar perimeter. This is the area of the scar active growth. However, this scar differs from “growing” keloid. The skin tone in the center of the scar now hardly differs from normal skin. This keloid is inactive and is in the status of regression. Such scars may be exposed to microneedle therapy with a share of reasonable risk.
4.2 Other major Medical Applications
ORTHOPEDIC APPLICATION
• The goal of treatment with platelet gel is to stimulate and speed the healing of connective tissues, which in turn has decreased pain, increased functional and physiological reparative tissue formation. • Indicated for articular pathologies, tendon and muscle of the knee, shoulder, wrist, hip, ankle, elbow: • Osteoporosis • Tendinopathy • Epicondylitis • Epitroclea • Gonarthrosis • Coxarthrosis • Rhizoarthrosis • Others
4.2 Other major Medical Applications GREEN CAP TUBE : CGF – LIQUID PHASE (LPCGF) WITH SODIUM HEPARIN
BLOOD COLLECTION AND VACUUM SEPARATION GREEN CAP TUBE
C.G.F. CONCENTRATED GROWTH FACTORS
–
LIQUID
PHASE
(LPCGF) WITH SODIUM HEPARIN •
Green cap tube: with phases separator Medifuge, you obtain a liquid phase with sodium heparin 18 U.L./ml blood for different infiltration treatments.
•
Preservation time 8 hours at 20°C
•
Preservation time 48 hours at 4°
4.2 Other major Medical Application
LAYERS OF THE CGF SYSTEM GREEN CAP - WITH SODIUMHEPARIN TO PREVENT COAGULATION
4.2 Other major Medical Applications TREATING ULCERS CALCIFICATIONS POST TRAUMATIC Dr. Ezio Gheno
TREATING ULCERS CALCIFICATIONS POST TRAUMATIC Dr. Ezio Gheno
4.2 Other major Medical Applications TREATING PUTRID ULCERS
4.2 Other major Medical Applications
PUTRID ULCERS THE HEALING AT 20 DAYS AFTER SURGERY
4.2 Other major Medical Applications
PUTRID ULCERS THE HEALING AT 30 DAYS AFTER SURGERY
4.2 Other major Medical Applications
TRIGEMINUS NEURALGIA (INFLAMMATION, REGENERATION)
Area of central lesions Sölder – lines (Nucl. spinalis)
Prof. Ottaviano Tapparo
Area of peripheral lesions
Prof. Ottaviano Tapparo
4.2 Other major Medical Applications TMJ REGENERATION (BONE, CARTILLAGE, SCLEROTIC OR INFLAMMATED TENDONS MUSCLES)
Prof. Ottaviano Tapparo
4.2 Other major Medical Applications TMJ REGENERATION (BONE, CARTILLAGE, SCLEROTIC OR INFLAMMATED TENDONS MUSCLES)
Prof. Ottaviano Tapparo
4.2 Other major Medical Applications
ATLAS INJECTION DORSALLY
Prof. Ottaviano Tapparo 52
4.2 Other major Medical Applications TORTICOLLIS FOR 8 YEARS – OUTCOME AFTER 3 TREATMENTS SESSIONS WITH AUTOLOGOUS STEM CELLS (CD 34+)
Prof. Ottaviano Tapparo
Prof. Ottaviano Tapparo
4.2 Other major Medical Applications
ARTICULACION GLENOHUMERAL ABORDAJE POSTERIOR
4.2 Other major Medical Applications
ARTICULACION GLENOHUMERL ABORDAJE ANTERIOR
4.2 Other major Medical Applications – – – – – – – –
TENDINOPATHIES INTERVERTEBRAL DISCS LIGAMENT SPRAINS NERVES MUSCLE STRAINS FRACTURE NON-UNION TS Oral and dental surgery
E.g. Achilles tendonitis Lateral/Medial epicondylitis Rotator Cuff Tendonitis Patella tendonitis Chronic Hamstring Labral tear shoulder Knee/Shoulder Arthritis
4.2 Other major Medical Applications Cystitis, vaginitis, injuries of the uterus, candidoses, staphylococcus
wounds,
vascular
ulcers,
diabetic
ulcers, decubitus ulcers, orthopedic bone, muscle and cartillage
surgery,
head
regeneration,
arthroses
fibromyalgia,
scars
of
and
and the deep
regeneration, teleangiektasien....
neck ts,
tendon pain
wrinkles,
in skin
5. Advantages and Disvantages
ADVANTAGES
• Biocompatibility, because it is a components of the patient. C.G.F. is completely autologous, naturally biocompatible, bioreasorbable and nonallergenic. • Simple, quick, with no downtime. The procedure takes only few minutes and daily routine can be resumed immediately after the injection. • Natural autologous system. The technical features of C.G.F. is to be a natural autologous system without any toxic agents. • No cases of adverse effect happened. Clinical and applied data indicate that C.G.F. doesn’t record any adverse effects in comparison with other competitors. • Rigorous safety controlled blood phase separator process. The system is manufactured in Italy under the highest quality standards with top qualified research engineers and latest technology. • LP C.G.F. autologous filler without the addition of exogenous substances (no chemical & animal vegetable).
5. Advantages and Disvantages
ADVANTAGES
•
Multi-action treatment. C.G.F. provides healing, antiinflammatory, antioxidant effects it stimulates collagen, and proteoglycan synthesis, and plays a significant role in the defensive function of the skin.
•
Resistance to degradation. Thanks to its technical feature, C.G.F. provides enhanced viscoelastic properties and a better resistance to enzymatic oxidative and thermal degradations.
•
Very high concentrated growth factors. Thanks to its characteristic process C.G.F. provides the highest platelet concentration.
•
Optimal physiological molecular weight. The working process: the blood drawing is done through an aseptic-safety system and no artificial or natural substances are additioned. The immediate centrifugation assures an aseptic working process. C.G.F. has an
5. Advantages and Disvantages
ADVANTAGES: PROCESSES PROMOTED BY CGF AND ITS MAIN CHARACTERISTICS •
It is a preparation of autologous.
•
Immunologically neutral.
•
Non-toxic.
•
Stimulating repair processes and growth tissue.
•
Stimulating cell proliferation.
•
Stimulating angiogenesis and revascularization.
•
Stimulating the proliferation of mesenchymal cells.
•
Stimulating the production of fibroblasts.
•
Accelerating wound healing.
•
Bio - Stimulating collagen production.
•
The thin, soft, elastic and permeable mesh allows to be colonized by repair cells, red and white blood cells, platelets
5. Advantages and Disvantages CONTROL CENTRIFUGE MEDIFUGESILFRADENT SERUM BUFF Y COAT RED BLOOD CELLS Buffy Coat Red- Buffy Coat Interface Red Blood 1 Red Blood 2 Red Blood 3
High Concetrated Growth Factors
5. Advantages and Disvantages
DISADVANTAGE •
The doctor need to collect the blood of the patience.
•
The doctor s must respect the Silfradent protocols.
•
Reduced time of application.
•
Do not perform on patients who are under chemotherapy, malignancy in the wound area, Emoglubina 10.5 g / o / l, Serum albumin 2.5 g / or / l, Platelets 100x10 g / l, Wounds declared clinically infectious.
•
The patient must have a good general health.
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing Round UP Technical Spesifications: • Equipped with a decontamination cycle with UVC reflected light • Cycle duration: 5 minutes • POWER SOURCE: 100: 115+/-10% | 50/60 Hz • WEIGHT: 19 Kg • DIMENSIONS: 320 P X 320 L X 300 H • NOMINAL POWER CONSUMPTION: 320 VA • RPM: 3600 r.p.m • TIMER: 1-16 sec
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing The Silfradent Round up is a medical devise that permits Intrinsic and Extrinsic molecular blender for plasma concentrates with autologous bone or bio-compatible additions. Product Features: • Medical device for intrinsic and extrinsic molecular blend, mixing with altering the geometric dimensions of autologous, heterologous or synthetic materials, for medical use. • The system is used with liquid, semiliquid or solid materials. • Perfect, homogenous mixing free from atmospheric contamination. • Automatic empty in just a few second: max 16 seconds. • Equipped with a decontamination cycle with UVC reflected light.
6. Related product (Round Up, & APAG) and accessories
COMBIOSS _ Pure B-Tricalcium Phosphate Completely reasorbable Interconecting Microporosity Bone Grafting material More than 99% phase. Pure B-Tricalcium Phosphate. Available in granules 315-500 (0.5 ml) and 500-100 (1.0 ml) micron Porosity about 70% C.G.F mixture is the ideal component for bone regrowth (visible after 45-60 days) Osteoinduction
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing CGF filler mixed with bioactivity: Totally Pure and Absorbable compound.
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing
Advanced research Round-Up = Forefront your Osteoinduction
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing
6. Related product (Round Up, & APAG) and accessories
A.P.A.G. FOR ACTIVATING PLASMA ALBUMIN GEL AND COLLAGEN
6. Related product (Round Up, & APAG) and accessories
MEDIFUGE + A.P.A.G GEL ACTIVATED PLASMA ALBUMIN GEL
6. Related product (Round Up, & APAG) and accessories
MEDIFUGE + A.P.A.G GEL ACTIVATED PLASMA ALBUMIN GEL
6. Related product (Round Up, & APAG) and accessories SIRINGES WITH CD 34+ AND ACTIVATED A.P.A.G. (AFTER COOLING 10 MIN)
CGF-application
99
6. Related product (Round Up, & APAG) and accessories SIRINGES AND MIXING DEVICE
6. Related product (Round Up, & APAG) and accessories READY TO USE FILLER
6. Related product (Round Up, & APAG) and accessories READY - TO - USE MATERIAL
6. Related product (Round Up, & APAG) and accessories
THE DENATURATION OF ALBUMIN OCCURS AT 75° DEGREES.
1ST PHASE The denaturation of albumin by heating leads to the construction of a web structure, scaffold. 2ND PHASE During cooling, the platelets homogenize the above mentioned structures.
What is “ A.P.A.G.” Gel It is derived from a sample of peripheral blood from the same patient; Skin ulcers and wounds that do not heal can have a significant impact on quality of life. Denaturalized Albumin with: Platelets, Cells CD34+ - autologous healing agents that stimulate the natural auto-healing induced starting from the wound bed with slow "Biphasic" release - prolonged by growth factors. ^ Gel- Plasma rich of platelets ( PPP Denaturalized Albumin A.P.A.G. + PRP + CD34+ ) for the treatment of chronic wounds and other. ^ It can be used for the treatment of exudative wounds, ulcers of the upper-lower extremities , pressure sores and diabetic ulcers. ^ It is a “Scaffold” of natural fibrin (derived from plasma) which acts as a scaffold for the adhesion of new cells. ^ The results are visible in a few days yet not weeks. ^ Promotes the healing process of wounds from post surgical trauma. ^ It helps to manage mechanically or surgically debrided wound (helps healing).
MEMBRANE EFFECTS ^ Antipyretic: it gives relief without burning ^ Analgesic: it reduces pain, even in depth ^ Moisturizing: it promotes blood fluid retention in the tissues ^ Fungicidal: it inhibits the growth of fungi ^ Hemostatic: it reduces bleeding ^ Bactericidal: it hinders the growth of bacteria ^ Virustatic: it hibits the growth and development of viruse ^ Detoxifying: it helps the tissue detoxification from previous chemical and pharmacological treatments ^ Proteolytic and Cicatrizant: it enzymatically dissolves and absorbs dead or damaged cells, stimulating the regeneration process
BIOGELS AND APAG Bio Gel for injections: Fibroblast stimulating gel Bio-Matrix Gel for filler
APPLICATION PRP PRP metodo / CGF: retrogressive
PPP technique: Injection or irrigation 3-way multiple injector x 27G x 4 mm
Luer Lock
PROTOCOL EXECUTED 1 ●
21 d
2 ●
21 d
3 ●
21 d
4 ●
21 d
5 ●
21 d
6 ●
Hair loss stops Miniaturization stops
6 months to 1 year: visible Global Changes
MINIATURIZATI ON Before
2 months after PRPO3
1° CYCLE PRP O3, 20122013
06 October 2012
07 December. 2012
12 January. 2013 4 months
JUVENTUTE - GREEN The continuous innovation in science and technologies in addition to many years of experience in the marketing of products and services in the world of aesthetics, is a characteristic of Silfradent Cosmetic.
JUVENTUTE - GREEN What is new in Juventute cosmetic line: Exclusive cosmetic line with buffer excipients that stabilized growth factors and CD34+ cells. Can enhance the results of existing protocols that use PRP, PRP gel and CGF. Can be mixed with vitamins as Vit. D and Vit. B and Melatonin (protocols by Silfradent)
JUVENTUTE • Helps the immune system with sensitive skin with
less collagen fibers • Stressed skin subjected to sun exposure, smoking, frequent cleansing and hair removal • Helps to reduce the effect of the changing seasons and temperatures ristoring the physiological pH
Juventute line INNOVATION Mask JUVENTUTE (Improve the stabilities of stem cells Green and the stability of the growth factors) • pH optimum, maintain physiological MCH conditions. Cream JUVENTUTE - Green • pH Buffers, prevents changes in pH • Controlled osmolarity CRE Balances the physiological pH of Lotion JUVENTUTE - Green-the skin. - Nutrient / antioxidant LOZ
CGF
CD34+
Juventut e
CD34 +
MASK JUVENTUTE GREEN
Special mask that combines innovative CGF autologous growth factors with precious natural
PERSONALIZED COSMETIC JUVENTUTE® (SILFRADENT®) PREPARATION
Face Mask Juventute® – Green MCH Preparation: Mix 8 gr of Juventute® - Green MCH with 3 ml of autologous PPP. Mix with homogenizer Round Up® (Silfradent®) for 14 sec. Professional use: apply in the same session after treatment with PRP. How to use: Do facial cleansing with cleansing milk, then apply a thin layer of mask. After 10-15 min remove very well with warm-cold water then toning with lotion Juventute® - Green LOZ. Before applying any other product, wait at least 20 min. Benefits: Juventute® - Green MCH mask carries a powerful anti-aging action, removing free radicals, the accumulation of toxic products of the skin and activating the endogenous antioxidant cutaneous systems. Juventute® - Green MCH is a nourishing innovative mask which combines autologous growth factors with precious natural active ingredients (Green Active Principles ).
CREAM JUVENTUTE GREEN
Potent anti-aging, rich in stem cells and autologous growth factors.
LOTION JUVENTUTE GREEN
15-20 min LOZ returns the normal physiological pH of the skin. Strong moisturizing effect.
LOTION JUVENTUTE - GREEN LOZ
Without addition of autologous or artificial preparations. Vial 200 ml. How to use and: Apply after the use of the mask Juventute - Green MCH or 15-30 minutes after the cream Juventute - Green CRE. The lotion should be stored between 4-8ºC and is stable for one month. Benefit: Lotion Juventute - Green LOZ returns the physiological pH of the skin to its normal and it has a strong hydrating effect (Green Active Substances).
RESULTS JUVENTUTE Aesthetic: micro-peeling effect, increased tone and brightness of the skin, enhances the natural color of the skin. Anti-Age: removal of toxic substances present in the skin, both external (pollution, smoke, etc.) and internal. Functionally: act as a "natural regeneration."
7. Study and clinical paper
THIS IS THE RESULT OBTAINED FROM MANY RESEARCHES AND STUDIES CONDUCTED BY FAMOUS UNIVERSITIES ALL OVER THE WORLD. Please visit the website www.silfradentasia.com
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
GROWTH FACTORS, CD34 POSITIVE CELLS, AND FIBRIN NETWORK ANALYSIS IN CONCENTRATED GROWTH FACTORS FRACTION LUIGI FABRIZIO RODELLA, GAIA FAVERO, RAMON BONINSEGNA, BARBARA BUFFOLI, MAURO LABANCA, GIORGIO SCARI`, LUIGI SACCO, TIZIANO BATANI, AND RITA REZZANI
Blood sample after separation without anticoagulant. Three layers are obtained: PPP - upper layer; CGF - middle layer; RBC - lower layer.
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
Immunohistochemical staining of TGF-b1 in CGF (A) and RBC (B) layers; immunohistochemical staining of VEGF in CGF (C) and RBC (D) layers. The graph showed the quantitative analysis (IOD) of TGF-b1 and VEGF expression in CGF and in RBC layers (E). Immunoblotting analysis of TGF-b1 and VEGF in CGF and RBC layers (F).
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
Immunohistochemical staining of CD34 in CGF (A) and RBC (B) layers. The graphs showed the number of CD34 positive cells in 10 hpf for ten sections in CGF and in RBC layers (C). *P < 0.05 versus RBC.
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
NEW BONE (NB) 30,40 +/- 0,57% NON- MINERALIZED TISSUE (N-MT) 34,52 +/- 1,42% RESIDUAL BONE GRAFT (RBG) 35,08 +/- 1,42% VESSELS (V)
Prof. L. F. Rodella Department of Biomedical Sciences and Biotechnologies, Division of Human Anatomy, University of Brescia
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
SEM analysis of CGF. Fibrin network (A) in which are trapped multiple platelet cell elements (B). The most important scaffold for all healing processes (healing is impossible without fibrin)
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
GROWTH FACTORS, CD34 POSITIVE CELLS, AND FIBRIN NETWORK ANALYSIS IN CONCENTRATED GROWTH FACTORS FRACTION LUIGI FABRIZIO RODELLA, GAIA FAVERO, RAMON BONINSEGNA, BARBARA BUFFOLI, MAURO LABANCA, GIORGIO SCARI`, LUIGI SACCO, TIZIANO BATANI, AND RITA REZZANI
ABSTRACT An interesting clinical option for optimizing healing tissue is the use of platelet concentrate. Platelets contain high quantities of growth factors, among these TGF-b1 and VEGF, which are known to be implicated in tissue regeneration. CGF is produced by processing blood samples with a special centrifuge device; three layers are formed: top acellular plasma (PPP), middle CGF and bottom red blood cells (RBC) layers. Given that to date there are no data concerning the biological characteristic of CGF, the aim of this study was to evaluate the presence of TGF-b1 and VEGF in CGF and also in PPP and RBC layers. In addition, since circulating stem cells are recruited from blood to injured tissue for healing we also evaluated the presence of CD34 positive cells. Our data show the presence of TGF-b1 and VEGF in CGF and RBC layers. In addition, we show CD34 positive cells in CGF. Microsc. Res. Tech. 74:772–777, 2011.
8.Technical specification for Round up
WE WANT TO CONTINUE OUR SCIENTIFIC TRAINING OF THIS TECHNIQUE OF GROWTH FACTOR BY ORGANIZING MANY COURSES AND SEMINARS. IF YOU ARE INTERESTING WITH THIS, IT WOULD BE OUR PLEASURE TO INFORM YOU OF OUR 2015 CALENDAR.
HANK YOU FOR YOUR ATTENTION!
NEW SCIENCE NEW SOLUTIONS NEW APPLICATIONS
CONTENT 1. Introduction to Silfradent Company and development of Medifuge 2. Medifuge and CGF. 3. How to use Medifuge? 4. Main CGF Medical Application 4.1 Dental Clinic Application 4.2 Other major Medical applications 5. Advantages and Disadvantage 6. Related product (Round Up, & APAG) and accessories 7.Study and clinical paper 8.Technical specification for Round up
1. Introduction of Sifradent Company
Silfradent is located in Santa Sofia, in the heart of a charming National Park, at the borders between Romagna and Tuscany provinces, in Italy. Since 1975 the Silfradent Company specializes in the production of instruments for dental laboratories, but since 2003 Silfradent also produces medical equipments. The constant of engineers, professors and doctors with its motivated staff and its organized distribution network of importers have helped Silfradent become the leading company in world in all of European Community, North Africa, Arabic countries, China, South Korea, South East Asia, Australia and the countries of South America and USA.
1. Introduction of Silfradent Company and development of Medifuge Today is the world leader in the most advance techniques of Growth Factors. Our scientific research and clinical outcomes demonstrate uniqueness and effectiveness of our new CGF system using Concentrated Growth Factors & Stem Cells. Silfradent offers a unique, incomparable, easy to handle and scientifically tested system. Reduce the pain and the intra & post-operative complication.
The MEDIFUGE CGF is designed to process blood to obtain CGF in a sterile environment so as not to contaminate the material to be implanted.
2. Introduction of Medifuge and CGF CGF - A dream of every doctor: A “fabulous” material that could cure all wounds quickly and avoid the secondary complications of surgical and medical procedures.
“Direct "effect of the growth factors Cytokines and CD 34 + cells Repair, regeneration, pain relief, Inflammation, minimizes swelling "Indirect" effect of growth factors, Cytokines and CD 34+ cells Signal transmission and thus more production growth factors and cytokines, as well as immigration into the tissue of other stem cells
2. Introduction of Medifuge and CGF
ROTOR PHASE SEPARATOR: SIFRADENT’S ADVANCE
•
Controlled acceleration
•
Cycle Bleaching sterilizing= decontamination
•
Antistatic, anti-magnetic rotor
•
Self-ventilation to control temperature
•
Deceleration control
•
Cooling
•
Temperature control
•
Self-decontamination
•
Rotor with alternate and controlled speed with an acceleration always under RCF300
2. Introduction of Medifuge and CGF
ROTOR SEPARATOR: SIFRADENT’S ADVANCE
PHASE
Rotor antistatic antimagnetic material (No influence on Fe in the red blood cells, minerals, heavy metals, decresaes cancer promoting substances as Aflatoxins, Cerium,Pollonium, eliminates Clostridium) Differentiated acceleration Speed and fractional – alternating RCF (does not allow the platelet degranulation) Constant temperature maintained by self ventilation
2. Introduction of Medifuge and CGF
ACCESSORIES’ MEDIFUGE
2. Introduction of Medifuge and CGF WHAT’S THE CGF? CGF – There is no blood manipulation CGF – It is a protein CGF – Stimulates – Accelerates natural biological events CGF – Block of fibrin and other blood-phases, a slow and continuous polymerization CGF – It transforms – It is an autologous material which don’t needs reabsorption CGF – Block fibrin flexible tri-molecular network – plasma cytokines stop in places/parking. CGF – Made with tissue fibroblasts are created – Made with bone osteoblasts are created. It doesn’t cause but accelerates the healing. CGF – Immunizing Anti edemigeno “swelling” Healing It acts in an intrinsic and extrinsic way CGF – Neo angiogenesis It rebuilds the blood vessels after 24 hours in the concave cavities where is necessary to accelerate the vascularization. Angio-vessel / Genesis-birth CGF – Immunogenic. It prevents the attack by bacteria and their fertility.
2. Introduction of Medifuge and CGF
WHAT’S THE CGF?
PDGF: Platelet Derived Growth Factor Promote the growth of blood vessels, cell replication, skin repair VEGF*: Vascular Endothelial Growth Factor Promote the formation of blood vessels EGF: Epidermal Growth Factor Promote cell growth and cell differentiation TGF-b*: Trasforming Growth Factor b Promote the growth of the extracellular matrix, the bone metabolism FGF-2*: Fibroblast Growth Factor-2 Promote cell growth and the formation of vessels IGF: Insulin-like Growth Factor Regulator of normal physiological processes of almost all types of body cells
2. Introduction of Medifuge and CGF
PROCESSES PROMOTED BY CGF AND ITS MAIN CHARACTERISTICS •
It is a preparation of autologous.
•
Immunologically neutral.
•
Non-toxic.
•
Stimulating repair processes and growth tissue.
•
Stimulating cell proliferation.
•
Stimulating angiogenesis and revascularization.
•
Stimulating the proliferation of mesenchymal cells.
•
Stimulating the production of fibroblasts.
•
Accelerating wound healing.
•
Bio - Stimulating collagen production.
•
The thin, soft, elastic and permeable mesh allows to be colonized by repair cells, red and white blood cells, platelets
3. How to use Medifuge? Collect the blood of the patient from 2 to 8 Vacuettes ® (tube) 18 cc (2 tubes) to 72 cc (=ml ) of blood red, white or green cap Put immediately in the Medifuge
3. How to use Medifuge? Safe & proper technique for routine blood draw
3. How to use Medifuge? Safe & proper technique for routine blood draw Steps • Apply the tourniquet • Palpate the antecubital fossa and locate the median cubital vein • Cleanse the skin around the site in a fluid • circular motion from the center to the periphery. • Position the needle bevel side up and linen with the vein in an ankle of maximum 30° • Draw blood • Instruct the client to open his hand and remove the tourniquet • Apply pressure in the puncture site immediately after and safe it with an adhesive bandage
3. How to use Medifuge? In each label there is the expiry date and the level of the quantity of blood need to collect =9 cc=9 ml
3. How to use Medifuge?
VACUTAINER® TUBES
Three types of Vacutainer and Applications of each separated part.
"Z serum clot activator" with Red cap internal coating by using silicon crystals in a coagulum the separation / centrifugation is done at room temperature
"Z No Additives" with White Cap no additional exogenous or coating here gelled a coagulum after separation / centrifugation after approximately 20 min at room temperature
"Sodium heparin" with Green Cap: Sodium heparin tube-fed to prevent the coagulation remain liquid at 20oC for 8 hours and at 4oC for 40 h. liquid
3. How to use Medifuge?
MEDIFUGE MF 200
Immediately after blood drawing (2 min.), set the vacutainers® opposite to each other in the Medifuge. Color-different cap tubes can be put together. Warning: Never put uneven tubes!
The load in a centrifuge must be carefully balanced. Use a combination of samples and balance tubes which all have the same weight or use various balancing patterns without balance tubes. Difference in mass of the tubes can result in a large force imbalance when the rotor is at high speed. This force imbalance strains the spindle and may result in damage to the centrifuge or personal injury.
3. How to use Medifuge? With the evolution of the CGF system , with Medifuge we obtain the 4 separated layers
4. Main CGF Medical Application Implantology, Oral Surgery, Peri-implantitis & Osteonecrosis Treatment, Bone Regeneration GBR, Tissue Regeneration GTR, Socket Preservation, Sinus Floor Elevation, IPG DET, Bone Grafting, Aesthetic of Peri-oral area, Biological Guided Periodontitis, ...... Trigeminus neuralgia TMJ regenerative therapy Facial Aesthetics, Autologous Messtherapy, Scars, Wrinkles, Skin regeneration & Hair aesthetics Biological Orthopaedic treatments for: bone, cartilage, sclerotic or inflamated tendons and muscles
4.1 Dental Application RED CAP TUBE : CGF – SOLID PHASE BLOOD COLLECTION AND VACUUM SEPARATION RED CAP TUBE
C.G.F.
CONCENTRATED
GROWTH FACTORS – SOLID PHASE •
Red
cap
tube
–
with
phases
separator
Medifuge, you
obtain a
fibrine clot platelet gel •
For
the
preparation
autologous
of
suturable
membrane, particulate to mix
with
autologous,
heterologous or synthetic bone.
4.1 Dental Clinic Application
3.1. RED CAP TUBE : CGF – SOLID PHASE LAYERS OF THE CGF SYSTEM RED CAP - WITH SILIZIUM COATING
4.1 Dental Clinic Application • In sinus lift procedures, CGF accelerates the healing and reduces the healing time with stable bone gain. • Ridge augmentation can be achieved with the use of CGF. • Socket preservation to maintain the alveolar bone height. • Intrabony defects or osseous defects have shown bone fill. • Optimal treatment for peri-implantitis. • Filling of cystic cavity. • Treatment of furcation defect. • Jaw reconstruction surgeries. • In the treatment of combined periodontic endodontic lesion. • Soft tissue procedures like gingival grafts, subepithelial grafts, and so forth, because of the property of GGF of accelerating soft tissue healing • Temporo Mandibular TMJ Articular Regeneration
4.1 Dental Clinic Application
MEMBRANES FOR GRAFTS COVERING
4.1 Dental Clinic Application
MEMBRANES FOR GRAFTS COVERING
4.1 Dental Clinic Application
MEMBRANES FOR GRAFTS COVERING
4.1 Dental Clinic Application
MEMBRANES FOR GRAFTS COVERING
4.1 Dental Clinic Application
MEMBRANE THAT POSSESSES ELASTICITY AND FLEXIBILITY
Image Dr. Ezio Gheno
4.1 Dental Clinic Application
4.1 Dental Clinic Application PERI-IMPLANTITIS & OSTEONECROSIS TREATMENT
4.1 Dental Clinic Application
CGF-CD34+Matrix & Peri-implantitis
Biological Guided Peri-iplantitis Treatment www.dentistedu.com
Bone reconstruction in 45 days
4.1 Dental Clinic Application
CGF-CD34+Matrix & Peri-implantitis Biological Guided Peri-implantitis Treatment
www.dentistedu.com
4.1 Dental Clinic Application
CGF-CD34+Matrix & Peri-implantitis Biological Guided Peri-iplantitis Treatment
Pre-op
3 months Post-op
3 years Post-op
“DentistEdu” special protocol for Peri-implantitis & Osteonecrosis Dentist Education Institute, Athens - Greece www.dentistedu.com
4.1 Dental Clinic Application
IPG DENTISTEDU DENTISTEDU TECHNIQUE TECHNIQUE IPG
I.P.GEORGAKOPOULOS ET ET ALL, ALL, JOURNAL JOURNAL OF OF IMPLANT IMPLANT AND AND ADVANCED ADVANCED CLINICAL CLINICAL I.P.GEORGAKOPOULOS DENTISTRY, VOLUME VOLUME 6, 6, NO NO 1, 1, 20-01-2014 20-01-2014 DENTISTRY,
Direct placement of seven implants in the posterior areas of the maxilla of a 49 year old female patient utilizing the flapless technique. The implants were introduced into both the sinus cavities with intentional perforation of the sinus membrane. CGF-CD34+ Matrix, Democritus' allograft & Combioss alloplastic bone materials were used in this case, following a certain protocol Dentist Education Institute, Athens - Greece
www.dentistedu.com
4.1 Dental Clinic Application
IPG DentistEdu Technique Results: 8 months Post-op
New bone formation around the implants I. P. Georgakopoulos et all, JIACD 2014
Almost 10 mm of new bone formation over the sinus floor
Conclusions: IPG-DentistEdu Technique promising results demonstrate that it can be considered as a reliable alternative to the SFE procedure.
4.1 Dental Clinic Application
IN THE SINUS LIFT PROCEDURE CGF ACCELERATES THE HEALING AND REDUCE THE HEALING TIME
After careful elevation of the sinus membrane, 4 pieces of fibrin-rich block were inserted into the new compartment between the elevated membrane and the sinus floor. Two tapered design implants were placed simultaneously after a 1-step down osteotomy. The
4.1 Dental Clinic Application
The piezoelectric saw, connected to piezoelectric device (Surgybone, Silfradent srl), was used to create the replaceable lateral window of maxillary sinus in all cases.
Cone-beam computed tomogram showing 1 to 2mm bone height at the right maxillary second (left) and first molar (right), respectively (from patient number 50).
4.1 Dental Clinic Application
The bony window was repositioned with stability to seal the window. f, Cone-beam computed tomographic scans revealed new bone consolidation along the implant body at the right maxillary second (left) and the first molar (right), respectively, after 18 weeks healing. Implants were uncovered at this stage.
Cone-beam computed tomogram showing 1 to 2mm bone height at the right maxillary second (left) and first molar (right), respectively (from patient number 50).
4.1 Dental Clinic Application
Radiogram after 5 months loading. Note the newly formed bone in the sinus.
4.1 Dental Clinic Application
IMPLANTOLOGY FASTER HEALING REDUCING COMPLICATIONS
4.1 Dental Clinic Application
BONE RING
4.1 Dental Clinic Application
BONE RING
4.1 Dental Clinic Application
BONE RING You mix the bone ring after drilling the implant site in the round up (6 sec.) and then fix the the bone ring with the implant.
BONE REGENERATION IN THE MAXILLARY SINUS USING AN AUTOLOGOUS FIBRIN-RICH BLOCK WITH CONCENTRATED GROWTH FACTORS ALONE Dong-Seok Sohn, DDS, PhD, Jeung-Uk Heo, DDS, PhD, Dong-Ho Kwak, DDS, PhD, Dong-Eung Kim, DDS, PhD, Ji-Min Kim, DDS, Jee-Won Moon, DDS, Ju-Hyoung Lee, DDS, and In-Sook Park, DDS, PhD
A fibrin-rich block with concentrated growth factors. The second and third layers were utilized for sinus augmentation.
4.2 Other major Medical Applications WHITE CAP TUBE : CGF – LIQUID PHASE (LPCGF) BLOOD COLLECTION AND VACUUM SEPARATION WHITE CAP TUBE
C.G.F.
CONCENTRATED
GROWTH FACTORS – LIQUID PHASE (LPCGF) •
White
cap
tube:
phases
with
separator
Medifuge, you obtain a liquid phase for infiltration treatments
to
be
used
within 20/30 minutes from the separation. •
After
this
separated naturally jells.
time
the
material
4.2 Other major Medical Applications
LAYERS OF THE CGF SYSTEM - WHITE CAP – WITHOUT COATING OR ADDITIONAL SUBSTANCES
4.2 Other major Medical Applications
AESTHETIC AND COSMETIC APPLICATION • Full face rejuvenation • Cell regeneration • Facial volumization • Acne scars • Facial aesthetic lipostructure • Elimination of spots tissue • Wrinkled neck and décolleté • Fine lines and wrinkles • Textural improvement • Dull dry skin • Backs of hands
• Areas with androgenetic alopecia or alopecia aerated
4.2 Other major Medical Applications
LOSS HAIR: AREAS WITH ANDROGENETIC ALOPECIA OR ALOPECIA AREATED
4.2 Other major Medical Applications
LPCGF ON LEFT EYE. BEFORE & 6 WEEKS AFTER PROCEDURE
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
TYPICAL SKIN DAMAGE DUE TO EXTENSIVE SUN– EXPOSURE AND NICOTINE ABUSE
SKIN REPAIR AFTER 6 WEEKS WITH LPCGF
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
STROKE WIDTH REDUCTION AND PIGMENTATION IMPROVEMENT AFTER CGF – LPGF PROCEDURES
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
IMPROVEMENT OF LAX SKIN
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
HAND REJUVENATION
Aesthetic treatment of Dr. Paola Pederzol
4.2 Other major Medical Applications
STRIAE AFTER 2 MONTHS
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
OILY SKIN, BIG PORES, BEFORE & AFTER LPCGF
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications
AGED SKIN WITH WRINKLES AND PIGMENTATION PROBLEMS 3 MONTHS AFTER LPCGF
Aesthetic treatment of Dr. Paola Pederzoli
4.2 Other major Medical Applications 4 SESSIONS OF MICRONEEDLING
4.2 Other major Medical Applications BURN SCARS 1 TREATMENT WITH CGF –
4.2 Other major Medical Applications
3 MONTHS POST-OP
4.2 Other major Medical Applications
BURN SCARS ON FOREARM
Improvement after 1 treatment, 3 month post-op. CGF – best choice for burn scars!
4.2 Other major Medical Applications
FACIAL BURN SCARS
3 months post-op
4.2 Other major Medical Applications
ONE TREATMENT 7 MONTHS POSTOP
4.2 Other major Medical Applications
Only in needled areas erythema improves significantly
4.2 Other major Medical Applications
Only in needled areas erythema improves significantly This might be a hint that erythema of “lasered” skin can be reduced by micro needling
4.2 Other major Medical Applications
In the left photo erythema is observed along the keloid scar perimeter. This is the area of the scar active growth. However, this scar differs from “growing” keloid. The skin tone in the center of the scar now hardly differs from normal skin. This keloid is inactive and is in the status of regression. Such scars may be exposed to microneedle therapy with a share of reasonable risk.
4.2 Other major Medical Applications
ORTHOPEDIC APPLICATION
• The goal of treatment with platelet gel is to stimulate and speed the healing of connective tissues, which in turn has decreased pain, increased functional and physiological reparative tissue formation. • Indicated for articular pathologies, tendon and muscle of the knee, shoulder, wrist, hip, ankle, elbow: • Osteoporosis • Tendinopathy • Epicondylitis • Epitroclea • Gonarthrosis • Coxarthrosis • Rhizoarthrosis • Others
4.2 Other major Medical Applications GREEN CAP TUBE : CGF – LIQUID PHASE (LPCGF) WITH SODIUM HEPARIN
BLOOD COLLECTION AND VACUUM SEPARATION GREEN CAP TUBE
C.G.F. CONCENTRATED GROWTH FACTORS
–
LIQUID
PHASE
(LPCGF) WITH SODIUM HEPARIN •
Green cap tube: with phases separator Medifuge, you obtain a liquid phase with sodium heparin 18 U.L./ml blood for different infiltration treatments.
•
Preservation time 8 hours at 20°C
•
Preservation time 48 hours at 4°
4.2 Other major Medical Application
LAYERS OF THE CGF SYSTEM GREEN CAP - WITH SODIUMHEPARIN TO PREVENT COAGULATION
4.2 Other major Medical Applications TREATING ULCERS CALCIFICATIONS POST TRAUMATIC Dr. Ezio Gheno
TREATING ULCERS CALCIFICATIONS POST TRAUMATIC Dr. Ezio Gheno
4.2 Other major Medical Applications TREATING PUTRID ULCERS
4.2 Other major Medical Applications
PUTRID ULCERS THE HEALING AT 20 DAYS AFTER SURGERY
4.2 Other major Medical Applications
PUTRID ULCERS THE HEALING AT 30 DAYS AFTER SURGERY
4.2 Other major Medical Applications
TRIGEMINUS NEURALGIA (INFLAMMATION, REGENERATION)
Area of central lesions Sölder – lines (Nucl. spinalis)
Prof. Ottaviano Tapparo
Area of peripheral lesions
Prof. Ottaviano Tapparo
4.2 Other major Medical Applications TMJ REGENERATION (BONE, CARTILLAGE, SCLEROTIC OR INFLAMMATED TENDONS MUSCLES)
Prof. Ottaviano Tapparo
4.2 Other major Medical Applications TMJ REGENERATION (BONE, CARTILLAGE, SCLEROTIC OR INFLAMMATED TENDONS MUSCLES)
Prof. Ottaviano Tapparo
4.2 Other major Medical Applications
ATLAS INJECTION DORSALLY
Prof. Ottaviano Tapparo 52
4.2 Other major Medical Applications TORTICOLLIS FOR 8 YEARS – OUTCOME AFTER 3 TREATMENTS SESSIONS WITH AUTOLOGOUS STEM CELLS (CD 34+)
Prof. Ottaviano Tapparo
Prof. Ottaviano Tapparo
4.2 Other major Medical Applications
ARTICULACION GLENOHUMERAL ABORDAJE POSTERIOR
4.2 Other major Medical Applications
ARTICULACION GLENOHUMERL ABORDAJE ANTERIOR
4.2 Other major Medical Applications – – – – – – – –
TENDINOPATHIES INTERVERTEBRAL DISCS LIGAMENT SPRAINS NERVES MUSCLE STRAINS FRACTURE NON-UNION TS Oral and dental surgery
E.g. Achilles tendonitis Lateral/Medial epicondylitis Rotator Cuff Tendonitis Patella tendonitis Chronic Hamstring Labral tear shoulder Knee/Shoulder Arthritis
4.2 Other major Medical Applications Cystitis, vaginitis, injuries of the uterus, candidoses, staphylococcus
wounds,
vascular
ulcers,
diabetic
ulcers, decubitus ulcers, orthopedic bone, muscle and cartillage
surgery,
head
regeneration,
arthroses
fibromyalgia,
scars
of
and
and the deep
regeneration, teleangiektasien....
neck ts,
tendon pain
wrinkles,
in skin
5. Advantages and Disvantages
ADVANTAGES
• Biocompatibility, because it is a components of the patient. C.G.F. is completely autologous, naturally biocompatible, bioreasorbable and nonallergenic. • Simple, quick, with no downtime. The procedure takes only few minutes and daily routine can be resumed immediately after the injection. • Natural autologous system. The technical features of C.G.F. is to be a natural autologous system without any toxic agents. • No cases of adverse effect happened. Clinical and applied data indicate that C.G.F. doesn’t record any adverse effects in comparison with other competitors. • Rigorous safety controlled blood phase separator process. The system is manufactured in Italy under the highest quality standards with top qualified research engineers and latest technology. • LP C.G.F. autologous filler without the addition of exogenous substances (no chemical & animal vegetable).
5. Advantages and Disvantages
ADVANTAGES
•
Multi-action treatment. C.G.F. provides healing, antiinflammatory, antioxidant effects it stimulates collagen, and proteoglycan synthesis, and plays a significant role in the defensive function of the skin.
•
Resistance to degradation. Thanks to its technical feature, C.G.F. provides enhanced viscoelastic properties and a better resistance to enzymatic oxidative and thermal degradations.
•
Very high concentrated growth factors. Thanks to its characteristic process C.G.F. provides the highest platelet concentration.
•
Optimal physiological molecular weight. The working process: the blood drawing is done through an aseptic-safety system and no artificial or natural substances are additioned. The immediate centrifugation assures an aseptic working process. C.G.F. has an
5. Advantages and Disvantages
ADVANTAGES: PROCESSES PROMOTED BY CGF AND ITS MAIN CHARACTERISTICS •
It is a preparation of autologous.
•
Immunologically neutral.
•
Non-toxic.
•
Stimulating repair processes and growth tissue.
•
Stimulating cell proliferation.
•
Stimulating angiogenesis and revascularization.
•
Stimulating the proliferation of mesenchymal cells.
•
Stimulating the production of fibroblasts.
•
Accelerating wound healing.
•
Bio - Stimulating collagen production.
•
The thin, soft, elastic and permeable mesh allows to be colonized by repair cells, red and white blood cells, platelets
5. Advantages and Disvantages CONTROL CENTRIFUGE MEDIFUGESILFRADENT SERUM BUFF Y COAT RED BLOOD CELLS Buffy Coat Red- Buffy Coat Interface Red Blood 1 Red Blood 2 Red Blood 3
High Concetrated Growth Factors
5. Advantages and Disvantages
DISADVANTAGE •
The doctor need to collect the blood of the patience.
•
The doctor s must respect the Silfradent protocols.
•
Reduced time of application.
•
Do not perform on patients who are under chemotherapy, malignancy in the wound area, Emoglubina 10.5 g / o / l, Serum albumin 2.5 g / or / l, Platelets 100x10 g / l, Wounds declared clinically infectious.
•
The patient must have a good general health.
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing Round UP Technical Spesifications: • Equipped with a decontamination cycle with UVC reflected light • Cycle duration: 5 minutes • POWER SOURCE: 100: 115+/-10% | 50/60 Hz • WEIGHT: 19 Kg • DIMENSIONS: 320 P X 320 L X 300 H • NOMINAL POWER CONSUMPTION: 320 VA • RPM: 3600 r.p.m • TIMER: 1-16 sec
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing The Silfradent Round up is a medical devise that permits Intrinsic and Extrinsic molecular blender for plasma concentrates with autologous bone or bio-compatible additions. Product Features: • Medical device for intrinsic and extrinsic molecular blend, mixing with altering the geometric dimensions of autologous, heterologous or synthetic materials, for medical use. • The system is used with liquid, semiliquid or solid materials. • Perfect, homogenous mixing free from atmospheric contamination. • Automatic empty in just a few second: max 16 seconds. • Equipped with a decontamination cycle with UVC reflected light.
6. Related product (Round Up, & APAG) and accessories
COMBIOSS _ Pure B-Tricalcium Phosphate Completely reasorbable Interconecting Microporosity Bone Grafting material More than 99% phase. Pure B-Tricalcium Phosphate. Available in granules 315-500 (0.5 ml) and 500-100 (1.0 ml) micron Porosity about 70% C.G.F mixture is the ideal component for bone regrowth (visible after 45-60 days) Osteoinduction
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing CGF filler mixed with bioactivity: Totally Pure and Absorbable compound.
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing
Advanced research Round-Up = Forefront your Osteoinduction
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing
6. Related product (Round Up, & APAG) and accessories
Round up- Integrated Mixing
6. Related product (Round Up, & APAG) and accessories
A.P.A.G. FOR ACTIVATING PLASMA ALBUMIN GEL AND COLLAGEN
6. Related product (Round Up, & APAG) and accessories
MEDIFUGE + A.P.A.G GEL ACTIVATED PLASMA ALBUMIN GEL
6. Related product (Round Up, & APAG) and accessories
MEDIFUGE + A.P.A.G GEL ACTIVATED PLASMA ALBUMIN GEL
6. Related product (Round Up, & APAG) and accessories SIRINGES WITH CD 34+ AND ACTIVATED A.P.A.G. (AFTER COOLING 10 MIN)
CGF-application
99
6. Related product (Round Up, & APAG) and accessories SIRINGES AND MIXING DEVICE
6. Related product (Round Up, & APAG) and accessories READY TO USE FILLER
6. Related product (Round Up, & APAG) and accessories READY - TO - USE MATERIAL
6. Related product (Round Up, & APAG) and accessories
THE DENATURATION OF ALBUMIN OCCURS AT 75° DEGREES.
1ST PHASE The denaturation of albumin by heating leads to the construction of a web structure, scaffold. 2ND PHASE During cooling, the platelets homogenize the above mentioned structures.
What is “ A.P.A.G.” Gel It is derived from a sample of peripheral blood from the same patient; Skin ulcers and wounds that do not heal can have a significant impact on quality of life. Denaturalized Albumin with: Platelets, Cells CD34+ - autologous healing agents that stimulate the natural auto-healing induced starting from the wound bed with slow "Biphasic" release - prolonged by growth factors. ^ Gel- Plasma rich of platelets ( PPP Denaturalized Albumin A.P.A.G. + PRP + CD34+ ) for the treatment of chronic wounds and other. ^ It can be used for the treatment of exudative wounds, ulcers of the upper-lower extremities , pressure sores and diabetic ulcers. ^ It is a “Scaffold” of natural fibrin (derived from plasma) which acts as a scaffold for the adhesion of new cells. ^ The results are visible in a few days yet not weeks. ^ Promotes the healing process of wounds from post surgical trauma. ^ It helps to manage mechanically or surgically debrided wound (helps healing).
MEMBRANE EFFECTS ^ Antipyretic: it gives relief without burning ^ Analgesic: it reduces pain, even in depth ^ Moisturizing: it promotes blood fluid retention in the tissues ^ Fungicidal: it inhibits the growth of fungi ^ Hemostatic: it reduces bleeding ^ Bactericidal: it hinders the growth of bacteria ^ Virustatic: it hibits the growth and development of viruse ^ Detoxifying: it helps the tissue detoxification from previous chemical and pharmacological treatments ^ Proteolytic and Cicatrizant: it enzymatically dissolves and absorbs dead or damaged cells, stimulating the regeneration process
BIOGELS AND APAG Bio Gel for injections: Fibroblast stimulating gel Bio-Matrix Gel for filler
APPLICATION PRP PRP metodo / CGF: retrogressive
PPP technique: Injection or irrigation 3-way multiple injector x 27G x 4 mm
Luer Lock
PROTOCOL EXECUTED 1 ●
21 d
2 ●
21 d
3 ●
21 d
4 ●
21 d
5 ●
21 d
6 ●
Hair loss stops Miniaturization stops
6 months to 1 year: visible Global Changes
MINIATURIZATI ON Before
2 months after PRPO3
1° CYCLE PRP O3, 20122013
06 October 2012
07 December. 2012
12 January. 2013 4 months
JUVENTUTE - GREEN The continuous innovation in science and technologies in addition to many years of experience in the marketing of products and services in the world of aesthetics, is a characteristic of Silfradent Cosmetic.
JUVENTUTE - GREEN What is new in Juventute cosmetic line: Exclusive cosmetic line with buffer excipients that stabilized growth factors and CD34+ cells. Can enhance the results of existing protocols that use PRP, PRP gel and CGF. Can be mixed with vitamins as Vit. D and Vit. B and Melatonin (protocols by Silfradent)
JUVENTUTE • Helps the immune system with sensitive skin with
less collagen fibers • Stressed skin subjected to sun exposure, smoking, frequent cleansing and hair removal • Helps to reduce the effect of the changing seasons and temperatures ristoring the physiological pH
Juventute line INNOVATION Mask JUVENTUTE (Improve the stabilities of stem cells Green and the stability of the growth factors) • pH optimum, maintain physiological MCH conditions. Cream JUVENTUTE - Green • pH Buffers, prevents changes in pH • Controlled osmolarity CRE Balances the physiological pH of Lotion JUVENTUTE - Green-the skin. - Nutrient / antioxidant LOZ
CGF
CD34+
Juventut e
CD34 +
MASK JUVENTUTE GREEN
Special mask that combines innovative CGF autologous growth factors with precious natural
PERSONALIZED COSMETIC JUVENTUTE® (SILFRADENT®) PREPARATION
Face Mask Juventute® – Green MCH Preparation: Mix 8 gr of Juventute® - Green MCH with 3 ml of autologous PPP. Mix with homogenizer Round Up® (Silfradent®) for 14 sec. Professional use: apply in the same session after treatment with PRP. How to use: Do facial cleansing with cleansing milk, then apply a thin layer of mask. After 10-15 min remove very well with warm-cold water then toning with lotion Juventute® - Green LOZ. Before applying any other product, wait at least 20 min. Benefits: Juventute® - Green MCH mask carries a powerful anti-aging action, removing free radicals, the accumulation of toxic products of the skin and activating the endogenous antioxidant cutaneous systems. Juventute® - Green MCH is a nourishing innovative mask which combines autologous growth factors with precious natural active ingredients (Green Active Principles ).
CREAM JUVENTUTE GREEN
Potent anti-aging, rich in stem cells and autologous growth factors.
LOTION JUVENTUTE GREEN
15-20 min LOZ returns the normal physiological pH of the skin. Strong moisturizing effect.
LOTION JUVENTUTE - GREEN LOZ
Without addition of autologous or artificial preparations. Vial 200 ml. How to use and: Apply after the use of the mask Juventute - Green MCH or 15-30 minutes after the cream Juventute - Green CRE. The lotion should be stored between 4-8ºC and is stable for one month. Benefit: Lotion Juventute - Green LOZ returns the physiological pH of the skin to its normal and it has a strong hydrating effect (Green Active Substances).
RESULTS JUVENTUTE Aesthetic: micro-peeling effect, increased tone and brightness of the skin, enhances the natural color of the skin. Anti-Age: removal of toxic substances present in the skin, both external (pollution, smoke, etc.) and internal. Functionally: act as a "natural regeneration."
7. Study and clinical paper
THIS IS THE RESULT OBTAINED FROM MANY RESEARCHES AND STUDIES CONDUCTED BY FAMOUS UNIVERSITIES ALL OVER THE WORLD. Please visit the website www.silfradentasia.com
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
GROWTH FACTORS, CD34 POSITIVE CELLS, AND FIBRIN NETWORK ANALYSIS IN CONCENTRATED GROWTH FACTORS FRACTION LUIGI FABRIZIO RODELLA, GAIA FAVERO, RAMON BONINSEGNA, BARBARA BUFFOLI, MAURO LABANCA, GIORGIO SCARI`, LUIGI SACCO, TIZIANO BATANI, AND RITA REZZANI
Blood sample after separation without anticoagulant. Three layers are obtained: PPP - upper layer; CGF - middle layer; RBC - lower layer.
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
Immunohistochemical staining of TGF-b1 in CGF (A) and RBC (B) layers; immunohistochemical staining of VEGF in CGF (C) and RBC (D) layers. The graph showed the quantitative analysis (IOD) of TGF-b1 and VEGF expression in CGF and in RBC layers (E). Immunoblotting analysis of TGF-b1 and VEGF in CGF and RBC layers (F).
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
Immunohistochemical staining of CD34 in CGF (A) and RBC (B) layers. The graphs showed the number of CD34 positive cells in 10 hpf for ten sections in CGF and in RBC layers (C). *P < 0.05 versus RBC.
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
NEW BONE (NB) 30,40 +/- 0,57% NON- MINERALIZED TISSUE (N-MT) 34,52 +/- 1,42% RESIDUAL BONE GRAFT (RBG) 35,08 +/- 1,42% VESSELS (V)
Prof. L. F. Rodella Department of Biomedical Sciences and Biotechnologies, Division of Human Anatomy, University of Brescia
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
SEM analysis of CGF. Fibrin network (A) in which are trapped multiple platelet cell elements (B). The most important scaffold for all healing processes (healing is impossible without fibrin)
MICROSCOPY RESEARCH AND TECHNIQUE 00:000–000 (2010)
GROWTH FACTORS, CD34 POSITIVE CELLS, AND FIBRIN NETWORK ANALYSIS IN CONCENTRATED GROWTH FACTORS FRACTION LUIGI FABRIZIO RODELLA, GAIA FAVERO, RAMON BONINSEGNA, BARBARA BUFFOLI, MAURO LABANCA, GIORGIO SCARI`, LUIGI SACCO, TIZIANO BATANI, AND RITA REZZANI
ABSTRACT An interesting clinical option for optimizing healing tissue is the use of platelet concentrate. Platelets contain high quantities of growth factors, among these TGF-b1 and VEGF, which are known to be implicated in tissue regeneration. CGF is produced by processing blood samples with a special centrifuge device; three layers are formed: top acellular plasma (PPP), middle CGF and bottom red blood cells (RBC) layers. Given that to date there are no data concerning the biological characteristic of CGF, the aim of this study was to evaluate the presence of TGF-b1 and VEGF in CGF and also in PPP and RBC layers. In addition, since circulating stem cells are recruited from blood to injured tissue for healing we also evaluated the presence of CD34 positive cells. Our data show the presence of TGF-b1 and VEGF in CGF and RBC layers. In addition, we show CD34 positive cells in CGF. Microsc. Res. Tech. 74:772–777, 2011.
8.Technical specification for Round up
WE WANT TO CONTINUE OUR SCIENTIFIC TRAINING OF THIS TECHNIQUE OF GROWTH FACTOR BY ORGANIZING MANY COURSES AND SEMINARS. IF YOU ARE INTERESTING WITH THIS, IT WOULD BE OUR PLEASURE TO INFORM YOU OF OUR 2015 CALENDAR.
HANK YOU FOR YOUR ATTENTION!
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