Cat Plastik 2p555k

CRITICAL APPRAISAL OF THE TOPICS

SCREEN FOR INITIAL VALIDITY AND RELEVANCE The article is from a peer-reviewed journal Object of the study is limited to animal, which is need more research to make it applicable in human.

The study was not sponsored by any organization that might influence the study design or results

SCREEN FOR INITIAL VALIDITY AND RELEVANCE The results, if valid, need more research for our practice, due to  this journal belongs to animal research This information will have a direct impact on the health of our patients & something they will care about, until it can be proven safely in human being. This information, if valid and proven safely in human, will require us to change our current practice

DETERMINE THE INTENT OF THE ARTICLE To compare the outcome of the use silver sulfadiazine (SSD) and olive oil in partial thickness burn

Clinical category

Description

Preferred Study Design

Therapy

Tests the effectiveness of a treatment, such as a drug, surgical procedure, or other intervention

Randomized, doubleblinded, placebocontrolled trial

Diagnosis

Measures the validity (is it dependable?) and reliability (will the same results be obtained every time?) of a diagnostic test, or evaluates the effectiveness of a test in detecting disease at a pre symptomatic stage when applied to a large population

Cross-sectional survey (comparing the new test with a reference standard)

Causation

Assesses whether a substance is related to the development of an illness or condition

Prognosis

Determines the outcome of a disease

Cohort or case-control

Longitudinal cohort study

LEVEL 1 OF EVIDENCE Therapy/Prevention, Aetiology/Harm

Prognosis

Diagnosis

1a SR (with homogeneity*) of RCTs

SR (with homogeneity*) of inception cohort studies; CDR† validated in different populations

SR (with homogeneity*) of Level 1 diagnostic studies; CDR† with 1b studies from different clinical centres

Level

1b

Individual RCT (with narrow Confidence Interval‡)

1c

All or none§

Individual inception Validating** cohort study cohort study with > with good††† reference 80% follow-up; standards; or CDR† CDR† validated in a tested within one clinical single population centre

All or none case-series

Absolute SpPins and SnNouts††

LEVEL 2 EVIDENCE Level

Therapy/Prevention, Aetiology/Harm

Prognosis

Diagnosis

2a

SR (with homogeneity* ) of cohort studies

SR (with homogeneity*) of either retrospective cohort studies or untreated control groups in RCTs

SR (with homogeneity*) of Level >2 diagnostic studies

2b

Individual cohort study (including low quality RCT; e.g., <80% follow-up)

Retrospective cohort study or follow-up of untreated control patients in an RCT; Derivation of CDR† or validated on split-sample§§§ only

Exploratory** cohort study with good†††reference standards; CDR† after derivation, or validated only on split-sample§§§ or databases

2c

"Outcomes" Research; Ecological studies

"Outcomes" Research

Level 3,4,5 of Evidence Level

Therapy/Prevention, Aetiology/Harm

Prognosis

Diagnosis

3a

SR (with homogeneity*) of casecontrol studies

SR (with homogeneity*) of 3b and better studies

3b

Individual Case-Control Study

Non-consecutive study; or without consistently applied reference standards

4

Case-series (and poor quality Case-series (and poor quality cohort and case-control prognostic cohort studies***) studies§§ )

Case-control study, poor or nonindependent reference standard

5

Expert opinion without explicit critical appraisal, or based on physiology, bench research or "first principles"

Expert opinion without explicit critical appraisal, or based on physiology, bench research or "first principles"

Expert opinion without explicit critical appraisal, or based on physiology, bench research or "first principles"

GRADES OF RECOMMENDATION A

consistent level 1 studies

B

consistent level 2 or 3 studies or extrapolations from level 1 studies

C

level 4 studies or extrapolations from level 2 or 3 studies

D

level 5 evidence or troublingly inconsistent or inconclusive studies of any level

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